Cerebral Blood Flow and Intracranial Pressure
نویسندگان
چکیده
Update in Anaesthesia | www.worldanaesthesia.org CEREBRAl BlooD FloW The brain is unusual in that it is only able to withstand very short periods of lack of blood supply (ischaemia). This is because neurones produce energy (ATP) almost entirely by oxidative metabolism of substrates including glucose and ketone bodies, with very limited capacity for anaerobic metabolism. Without oxygen, energydependent processes cease, leading to irreversible cellular injury if blood flow is not re-established rapidly (3 to 8 minutes under most circumstances). Therefore, adequate cerebral blood flow must be maintained to ensure a constant delivery of oxygen and substrates, and to remove the waste products of metabolism.
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